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Title of the Collaborating Centre
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WHO Collaborating Centre for Traditional Medicine
Institution name : East-West Medical Research Institute, Kyung Hee University
Exact name of the department which acts as the WHO Collaborating Centre
: 8 Divisions of Institute
City and country of location : Seoul, Korea |
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| 1. Implementation of the work plan for each main activity |
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1.1. Work performed in relation to the terms of reference |
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1.1.1. KRF(Korea Research Foundation) Research Project |
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KRF research project finished in September 2007. This project entitled ‘Fundamental and clinical studies applying East-West medicine to strengthen international competitiveness and to globalize Korean Oriental medicine.’ The grant consisted of $240,000 from the government and $120,000 from Kyung Hee University in 2006. Professor Jin-Il Kim, director of this institute, is leading this project as a principle investigator.
Purposes of project : This project aimed to complete the ultimate goal set by the institution to promote the type of "research on East-West medical treatment to strengthen the international competitiveness of Korean Oriental medicine, first, by elaborating a feasible research model with which the Eastern and the Western medicine can work together, second, by globalizing the resources of Korean Oriental medicine, and by building up a network of information system through which the knowledge of Korean Oriental medicine can be purveyed all over the world. |
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Contents of Research :
Research
Period |
October 2006 ~ September 2007 (6th year / 6year) |
| Purpose |
Constructing the basis of 'research of East-West medical treatment for the strengthening of the international competitiveness of Korean Oriental medicine' |
| Detail |
Constructing an academic infra for better education and research by facilitating international interchanges |
Main
Theme |
◎ Study of clinical treatments in East-West medical sciences
ㆍClinical research on the evaluation of treatments for arthritis
ㆍIdentification of specific genes related to the pain mechanism in the centralnervous system
◎ Development of applicable therapeutic modules in Korean Oriental medicine
ㆍDeveloping new medicine
ㆍDeveloping diagnostic and therapeutic machines
ㆍInvestigation of the working mechanism of the Korean Oriental medicine
◎ Globalization of the teaching staff
ㆍEstablishment of lectures to improve their foreign language skills
ㆍDeveloping a foreign M.D. Acupuncture Program
ㆍInternational seminars on East-West medical sciences
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This work was supported by grant KRF-2005-005-J00701 and KRF-2005-005-J00702 from the Korea Research Foundation and Kyung Hee University.
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| 1.1.2. Research papers published in 2007 |
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| (1) |
Sun Kwang Kim, Hak Jin Moon, Jung Hyuk Park, Giseog Lee, Min-Kyu Shin, Moo-Chang Hong, Hyunsu Bae, Young-Ho Jin, Byung-Il Min
The maintenance of individual differences in the sensitivity of acute and neuropathic pain behaviors to electroacupuncture in rats
Brain Research Bulletin 74 (2007) 357-360 |
| (2) |
Youngseop Lee, Sun Kwang Kim, Yangseok Kim, Hyejung Lee, Min-Kyu Shin, Moo-Chang Hong, Byung-Il Min, Hyunsu Bae
The a-adrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice
Neuroscience Letters 423 (2007) 149-152 |
| (3) |
Dong Hyun Kim, Su Jin Jeon, Kun Ho Son, Ji Wook Jung, Seungjoo Lee, Byung Hoon Yoon, Jong-Ju Lee, Young-Wuk Cho, Jae Hoon Cheong, Kwang Ho Ko, Jong Hoon Ryu
The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice
Neurobiology of Learning and Memory 87 (2007) 536-546 |
| (4) |
Byung Hoon Yoon, Ji Wook Jung, Jong-Ju Lee, Young-Wuk Cho, Choon-Gon Jang, Changbae Jin, Tae Hwan Oh, Jong Hoon Ryu
Anxiolytic-like effects of sinapic acid in mice
Life Sciences 81 (2007) 234-240 |
| (5) |
Hyun-Jin Kim, Chun-Pill Choi, Yoon Kyung Uhm, Young Il Kim, Jin-Woo Lee, Seo Hyun Yoon, Joo-Ho Chung, Mu-Hyoung Lee
The association between endothelin-1 gene polymorphisms and susceptibility to vitiligo in a Korean population
Experimental Dermatology, 16, 561-566 |
| (6) |
Chun-Pill Choi, Young Il Kim, Jin-Woo Kim, Mu-Hyoung Lee
The effect of narrowband ultraviolet B on the expression of matrix metalloproteinase-1, transforming growth factor-ß1 and typeⅠcollagen in human skin fibroblasts
Clinical and Experimental Dermatology, 32, 180-185 |
| (7) |
Seung Geun Yeo, Dong Choon Park, Seok Min Hong, Chang Il Cha, Myung Gu Kim
Bacteriology of chronic suppurative otitis media - a multicenter study
Acta Oto-Laryngologica, 2007; 127: 1062-1067 |
| (8) |
Seung Geun Yeo, Dong Choon Park, Young Gyu Eun, Chang Il Cha
The role of allergic rhinitis in the development of otitis media with effusion: effect on eustachian tube function
American Journal of Otolaryngology-Head and Neck Medicine and Surgery 28 (2007) 148-152 |
| (9) |
Sung Wan Kim, Joong Saeng Cho, Jae Kyung Park, Kun Hee Lee, Chang Il Cha
Expression of Cytokines in Coculture Model with Epithelial Cells and Fibroblasts of Nasal Polyp
Korean J Otolaryngol 2007; 50: 134-138 |
| (10) |
Bum Soo Park, Jin Il Kim, Sun-Ju Lee
Comparison of Recovery Periods according to Treatment Modalities in Zoster-associated Voiding Dysfunction
J. Korean Continence Society 2007; 11: 36-40 |
| (11) |
Chang Hwa Jung,, Chan-Yong Jun, Sundong Lee, Chong-Hyeong Park, Kiho Cho, Seong-Gyu Ko
Rhus verniciflua Stokes Extract: Radical Scavenging Activities and Protective Effects on H2O2-Induced Cytotoxicity in Macrophage RAW 264.7 Cell Lines
Biol. Pharm. Bull. 29(8) 1603-1607 (2006) |
| (12) |
Chang Hwa Jung, Myung Hee Hong, Ji Hye Kim, Ji Yun Lee, Seong Gyu Ko, Kiho Cho, Ho Moon Seog
Protective effect of a phenolic-rich fraction from Schisandra chinensis against H2O2-induced apoptosis in SH-SY5Y cells
Journal of Pharmacy and Pharmacology 2007, 59: 455-462 |
| (13) |
Sang Pil Yun, Woo Sang Jung, Sung Uk Park, Sang Kwan Moon, Jung Mi Park, Chang Nam Ko, Ki Ho Cho, Young Suk Kim, Hyung Sup Bae
Hwangryunhaedogtang (Huanglianjiedutang) Treatment for Pathological Laughter after Stroke and Importance of Patterns Identification: A Preliminary Study
The American Journal of Chinese Medicine 35, 5, 725-733, 2007 |
| (14) |
Jun Mo Kang, Hi Joon Park, Yeong Gon Choi, Il Hwan Choe, Jae Hyun Park
Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced Mouse Model
Brain Research 1131 (2007) 211-219 |
| (15) |
Chang Eun Park, Min-Jung Kim, Jong Hwa Lee, Byung-Il Min, Hyunsu Bae, Wonchae Choe, Sng-Soo Kim, Joohun Ha
Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
Experimental and Molecular Medicine 39, 2, 222-229, 2007 |
| (16) |
Hwan-Suck Chung, Moonkyu Kang, Chongwoon Cho, Shoukat Parvez, Chong-heong Park, Dongwoo Kim, Joonghwan Oh, Hongyeoul Kim, Minkyu Shin, Moochang Hong, Yangseok Kim, Hyunsu Bae
Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages
Biol. Pharm. Bull. 30(5) 912-916 (2007) |
| (17) |
Shoukat Parvez, Moonkyu Kang, Hwan-Suck Chung, Hyunsu Bae
Naturally Occurring Tyrosinase Inhibitors: Mechanism and Applications in Skin Health, Cosmetics and Agriculture Industries
Phytotherapy Research 21, 805-816 (2007) |
| (18) |
Moonkyu Kang, Jong-Hoon Kim, Chongwoon Cho, Hwan-Suck Chung, Chang-Woon Kang, Yangseok Kim, Minkyu Shin, Moochang Hong, Hyunsu Bae
Anti-ischemic effect of Aurantii Fructus on contractile dysfunction of ischemic and reperfused rat heart
Journal of Ethnopharmacology 111 (2007) 584-591 |
| (19) |
Chang Hwa Jung, Hee Jung, Yong-Cheol Shin, Jong-Hyeong Park, Chan-Yong Jun, Hyung-Min Kim, Hee-Sun Yim, Min-Gyu Shin, Hyun-Soo Bae, Sung-Hoon Kim, Seong-Gyu Ko
Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage
Journal of Ethnopharmacology 113 (2007) 183-187 |
| (20) |
Hye-jung Chan, Sang-min Hong, You-seon Park, Dong-woo Nam, Doo-ik Lee, Jae-dong Lee, Yun-ho Lee, Sabina Lim
Economic Evaluation of Eastern, Western and Collaborative Treatments for Patients with Frozen Shoulder Pain
J Korean Oriental Med 2007; 28(1): 72-86 |
| (21) |
Mi-young Jeong, Hi-joon Park, Jee-haeng Jeong, Jin-young Kim, Jun-mo Kang, Na-Kyeong Lee, Sabina Lim
Inhibitory Effect of Angelica gigas Nakai Extract on Nitric Oxide Production in RAW 264.7 Cells
J Korean Oriental Med 2007; 28(2): 155-165 |
| (22) |
Hyung-jin So, Jae-hwan Ryu, Young-chul Kim, Beom-jun Lee
Clinical Analysis of Patients Who Visited the Emergency Room of an Oriental Medical Center
J Korean Oriental Med 2007; 28(3): 197-206 |
| (23) |
Nam Dong-woo, Lim Sabina, Kim Jong-in, Kim Keon-sik, Lee Doo-ik, Lee Jae-dong, Lee Yun-ho, Choi Do-young
Clinical Observation of Acupuncture and Nerve Block Treatment for Adhesive Capsulitis Patients
The Journal of Korean Acupuncture & Moxibustion Society 24(4) 2007, 143-155 |
| (24) |
Kim Chan-young, Kwon Na-hyoun, Shin Ye-ji, Nam Dong-woo, Kim Kun-hyung, Kim Jong-in, Choi Do-young, Lee Yun-Ho, Lee Jae-Dong
Randomized Controlled Trial : Effect of Master Dong's Acupuncture in Chronic Shoulder pain Patients
The Journal of Korean Acupuncture & Moxibustion Society 24(6) 2007, 89-96 |
| (25) |
Keun-Yung Yook, Seung-Ho Lee, Young-Kon Kim, Sabina Lim
Safety of Electromagnetic Field Made by Intelligent Thermo-Acupuncture System
Journal of Meridian & Acupoint 24(4), 69-84, 2007 |
| (26) |
Seung-Ki Choi, Bo-Rim Seo, Kyung-Won Lee, Woong Cho, Seoung-Hee Jeong, Kyung-Tae Lee
Saucernetin-7 Isolated from Saururus chinensis Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells
Biol. Pharm. Bull. 30(8) 1516-1522 (2007) |
| (27) |
Kyung-Jin Yun, Byung-Sun Min, Ji-Yeon Kim, Kyung-Tae Lee
Styraxoside A Isolated from the Stem Bark of Styrax japonica Inhibits Lipopolysaccharide-Induced Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cells by Suppressing Nuclear Factor-kappa B Activation
Biol. Pharm. Bull. 30(1) 139-144 (2007) |
| (28) |
Bae Eun-Ah, Sung-Won Min, Bomi Lee, Nam-Jae Kim, Nam-In Baek, Eun-Joo Han, Hae-Gon Chung, Dong-Hyun Kim
Antiasthmic Effect of Fermented Artemisia princeps in Asthmic Mice Induced by Ovalbumin
J. Microbiol. Biotechnol. (2007), 17(9), 1554-1557 |
| (29) |
Tae Woo Kim, Hyuck-Jai Choi, Nam-Jae Kim
Anxiolytic-like Effects of Saponin and Polysaccharide Fractions Extracted from White and Red Ginsengs in the Elevated Plus-Maze Model
J. Ginseng Res. 31(4), 217-221 (2007) |
| (30) |
Hyuck Jae Choi, Eun Jin Kim, Myung Joo Han, Nam In Baek, Dong Hyun Kim, Hae Gon Jung, Nam Jae Kim
Hepatoprotective Effect of Fermented Artemisia princeps PAMPANINI by Lactic Acid Bacteria
Kor. J. Pharmacogn. 38(3): 245-253 (2007) |
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Among these papers, (1)-(8), (11)-(19), (26)-(29) were published in English. |
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1.1.3. Publications in 2007 |
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| (1) |
East-West Medical Research Institute Journal 2006
This book contains 30 articles which were researched and published in this institute. |
| (2) |
Proceedings of The 2nd International East-West Cancer Symposium
This book contains 17 articles which were presented on the symposium organized by East-West Neo Medical Center and East-West Medical Research Institute. |
| (3) |
Proceedings of The 11th International Conference on Oriental Medicine 2007
This book contains 14 articles which were presented on the symposium organized by Institute of Oriental Medicine, College of Oriental Medicine of Kyung Hee University and East-West Medical Research Institute. |
| (4) |
Invitation to Clinical Traditional Chinese Medicine
Professor Ki-Ho Cho(Vice-Director, East-West Medical Research Institute) compiled 'East-West Medical Interpretation of Oriental Medicine Prescription at 2006 by IRIE, Yoshifumi'. |
| (5) |
Tongue Diagnosis for Clinicians - Integrating Oriental and Western Medicines
Professor Ki-Ho Cho(Vice-Director, East-West Medical Research Institute) compiled 'Tongue Diagnosis for Clinicians - Integrating Oriental and Western Medicines at 2005 by BEPPU Satoshi'. |
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1.2. Further Activities |
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1.2.1. International Symposium / Conference |
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- Outline of the International Symposium : |
| Title |
The 2nd International East-West Cancer Symposium |
| Date |
27-28 March 2007 |
| Venue |
Sheraton Grande Walkerhill Hotel, Convention Center, Seoul, Korea |
| Host |
East-West medical Research Institute, KyungHeeUniversity
M.μ Integrative Cancer Center, East-West Neo Medical Center, Kyung Hee University
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| Support |
· to identify the willingness of developing ICEATM ; |
Participated
Nations |
Korea, China, Japan, Taiwan, Hong Kong, Russia, WHO |
| Outputs |
Proceedings of The 2nd International East-West Cancer Symposium |
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- Outline of the International Conference
| Title |
The 11th International Conference on Oriental Medicine 2007 |
| Subject |
Oriental Medicine as Evidence Based Medicine 2007 |
| Date |
25 October 2007 |
| Venue |
COEXConferenceCenter, Room 320, Seoul, Korea |
| Host |
East-West medical Research Institute, KyungHeeUniversity
Institute of Oriental Medicine, KyungHeeUniversity
College of Oriental Medicine, KyungHeeUniversity
Brain Korea 21
OrientalMedicalScienceCenter, KyungHeeUniversity
OrientalMedicineResearchCenter for Stroke, Korea Institute of Oriental Medicine
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| Support |
· JungAng Ilbo |
Participated
Nations |
Korea, Japan, Vietnam, USA |
| Outputs |
Proceedings of The 11th International Conference on Oriental Medicine 2007 |
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1.2.2. Foreign Visitors |
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- Dr. Edwin L. Cooper(Founding Editor in Chief of eCAM) and Ms. Patty Christiena Willis(Founding International Administrator of eCAM) visited the institute on 20 June 2007. |
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1.2.3. Newly acquired research equipments in 2007 |
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- Ice Maker
- Thernal Cycler
- Electronic Balance |
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| 2. Collaboration between the centre and the WHO |
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2.1. Visits by WHO staff (HQ and /or Regional Office) to the centre
- None |
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2.2. Visits by centre staff to the WHO (HQ and /or Regional Office)
- None |
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2.3. Use of the centre staff by WHO
We were requested to support and collaborate on a project on traditional medicine from the WHO/HQ. There were four items during the year of 2007, and all of them were answered.
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| (1) |
WHO guidelines on basic training and safety in Tui Na(Chinese Remedial Massage)
- Dr. Xiaorui Zhang, Coordinator, Traditional Medicine, Department of Technical Collaboration for Essential Drugs and Traditional Medicine; from 8 March 2007 to May 2007 |
| (2) |
WHO guidelines on quality for safety of hmoeopathic medicines
- Dr. Xiaorui Zhang, from 28 March 2007 to May 2007 |
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WHO guidelines on basic training and safety in Thai Traditional Massage
- Dr. Xiaorui Zhang, from 26 April 2007 to July 2007 |
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WHO guidelines for the selection of substances for quality control of herbal medicines
- Dr. Xiaorui Zhang, from May 2007 to August 2007 |
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2.4. Support provided by centre staff for courses cosponsored or organized by the WHO (HQ and /or Regional Office) |
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Standardization of Traditional Processing Methodology of Herbal Materials for GMP Guideline, Seoul, Korea, 9-11 May 2007
- Prof. Nam-Jae Kim(Chief, Division of Pharmacological Study) attended the meeting as a participant. |
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Invitation to the 50th Anniversary Celebration National Hospital of Traditional Medicine, Hanoi, Vietnam, 6-7 June 2007
- Prof. Jin-Il Kim(Director) attended the meeting as a participant.
- Prof. Ki-Ho Cho(Deputy-Director) attended the meeting as a participant.
- Dr. Young-Il Kim(Researcher, Central Research Laboratory) attended the meeting as an observer. |
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International Classification of Traditional Medicine Western Pacific Regional Office
Proposal to WHOFIC Family Development Committee for inclusion of ICTM/WPRO in the World Health Organization Family of International Classifications, Brisbane, Australia, 26-29 August 2007
- Assistant Professor Bum-Sang Shim(Researcher, Division of Acupuncture & Meridian) attended the meeting as a participant |
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2.5. WHO financial support to the centre through contractual or Technical Services Agreement
- None |
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2.6. Other type of support provided by the WHO
- None |
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2.7. Any other collaborative activities
- None |
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2.8. Any difficulties encountered in the collaboration
- None |
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2.9. Suggestions for increased and improved collaboration with the WHO
- None |
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3. Collaboration with other WHO collaborating centres
- None |
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| 4. Research works to be planned in 2008 |
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4.1. NIS WIST (National Institute for Supporting Women in Science and Technology) Research Project |
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Contents of Research :
Research
Period |
January 2008 ~ September 2008 (1th year / 1year) |
| Purpose |
Programs Development and System Improvement for Enhancement of Capacity Building for Women in S & T |
| Detail |
· Survey on research environment of women in S & T
· Developing efficient educational training and enhancing of capacity for women scientists and engineers |
Main
Theme |
1. Survey on research environment of faculties and graduate students in S&T
- Survey on faculties and graduate students in S&T about research and educational problems.
- Find environmental problems of research and educating system in S&T.
- Develope a programs of enhancement of capacity building for Women in S&T.
- Course and career development for post-doctoral researcher.
2. Leadership development of women faculties in S&T
- Developing the leadership of women faculties in S&T through the meetings between women leaders(scientific, political and economic leaders) and women faculties.
- Reinforcement influences of women faculties for decision making through the meetings with assigned professors.
3. Revitalization of women faculty community
- Promotion mutual exchanges among women faculties.
- Promotion information sharing and forming network among women scientistsand engineers.
4. Mentoring programs for next generate women scientist and engineer
- Building networks between women faculties and students to support research activities and career development of women in S&T.
- Building Mentoring programs to promote women students self-esteem andcareer development.
5. Improvement welfare and environment for women scientists and engineers
- Establish family-friendly policy to combine work and family responsibilities.
- Build welfare facilities for women in S&T such as child-care facilities.
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4.2. Personal research works to be planned |
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| (1) |
Byung-Il Min
ㆍThe spinal musarinic mechanism of relieving effects of electroacupuncture on thermal allodynia
ㆍThe synergistic effects of neostigmine and EA on thermal allodynia ain a rat model of neuropathic pain
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Seung-Geun Yeo
ㆍThe protective effect of L-N-nitroarginine methyl ester (L-NAME) and N-acethyl L-cysteine (L-NAC) for the aging process in the central auditory system of the mice
ㆍExpression of Bcl-6, Blimp-1, Pax-5, XBP-1 mRNA in otitis media with effusion (OME)
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Young-Wuk Cho
ㆍSerotonergic modulation of oxidative stress in ischemic brain injury
ㆍGene and protein expression in ischemic brain injury
ㆍRole of NKCC and KCC in osmolar homeostasis
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Ki-Ho Cho
ㆍThe effect of Korean-medicine Treatment in Comparison to East-West combined Treatment on Acute peripheral Facial Palsy
ㆍThe development of and East-West Diagnosis Standardization on Cerebrovascular disease
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Sabina Lim
ㆍDevelopment of medical machines for diagnosis and treatment in Korean Medicine
ㆍStudies on safety and effectiveness of heat therapeutic apparatus with acupuncturethermo-meedle equipped with magnetic substance
ㆍDevelopments of anti-advanced glycation end products(AGEs) antibody and medical therapeutics by studies on the accumulation of AGEs in the brains of MPTP-inducedParkinsonism model(항-advanced glycatio)
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Hyun-Su Bae
ㆍDevelopment of cancer preventive & immunomodulatory materials from herbs
ㆍThe mechanism of electroacupuncture-induced immunomodulation in mice
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Jong-In Kim
ㆍEffect of Acupuncture on Side Effects of Anti-Cancer Treatments
ㆍThe effect of Bee venom herbal acupuncture on prevention and improvement of MPTP-induced neuronal death in the nigrostriatal dopaminergic system in the mice Parkinson's disease Model
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Nam-Jae Kim
ㆍStudies on the Development of Anti-oxidative Drugs from the Oriental Medicines
ㆍStudies on the Chemical Constituents and Biological Activities from the Natural Products
ㆍStudies on the Standardization of Herbal Medicines
ㆍStudies on the Efficacy of Combined Preparation of Crude Drug
ㆍStudies on the Crude Drug Processing
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Kyung-Tae Lee
ㆍStudies on the evaluation and the molecular mechanism of apoptosis and differentiation induced by natural or synthetic compounds
ㆍEvaluation of in vitro and in vivo anti-inflammatory activities of various natural compounds and identification of their pharmacological mechanism
ㆍScreening and mechanism of cell-cycle inhibitors isolated from natural compounds
ㆍIn vivo and in vitro nephroprotective and hepatoprotective effects of natural products
ㆍComparative biological activities of aglycon and glycoside natural compounds
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Yeong-Gon Choi
ㆍDevelopments of anti-advanced glycation end products(AGEs) antibody and medical therapeutics by studies on the accumulation of AGEs in the brains of MPTP-inducedParkinsonism model
ㆍAssociation of advanced glycation end products and alpha-synuclein in MPTP-induced parkinsonism model
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| (11) |
Jae-KyungPark
ㆍInduction of apoptosis by peroxisome proliferator-activated receptor γ in human cholangiocarcinoma
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| (12) |
Young-Il Kim
ㆍMethylation of inhibition alpha promoter gene in human gastric cancer cell lines
ㆍEffects of toll-like receptor2 and 4 by 15-deoxy-Δ12.14-prostglandin J2 in human keratinocytes
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| (13) |
Jin-Woo Lee
ㆍInduction of growth inhibition and apoptosis by sorafenib in human cholangio- carcinoma
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