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Title
of the Collaborating Centre
:
WHO Collaborating Centre for Traditional
Medicine
Institution name : East-West Medical Research
Institute, Kyung Hee University
Exact name of the department which acts as
the WHO Collaborating Centre
:
8 Divisions of Institute
City and country of location : Seoul, Korea |
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1.
Implementation of the work plan for each main activity
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1.1. Work performed in relation to the terms
of reference |
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1.1.1. KRF (Korea Research Foundation) Research
Project |
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The Institute received funds from the Korea
Research Foundation in October 2001 as a new government
research project, which is a 6-year program. The grant
consisted of $300,000 from the government and $209,000
from Kyung Hee University in 2004. The title of this project
is ‘Research of East-West medical treatment to strengthen
the international competitiveness of Korean Oriental medicine’,
and the principle investigator of this project was professor
Young-Seol Kim, former director of this institute.
Purpose of Research : The university chooses ‘research
of East-West medical treatment to strengthen the international
competitiveness of Korean Oriental medicine,?? as the
research subject of the institute, subdivides as the promotion
domain ??globalization and strengthening of the competitiveness
of Korean Oriental medicine,?? and emphasizes ① constructing
a collaborative research system of Eastern medicine and
Western medicine, ② globalizing the resources of Korean
Oriental medicine, and ③ informationalizing the knowledge
of Korean Oriental medicine as the main themes.
Contents of Research :
This work is supported by grant KRF-2001-005-F00024 and
KRF-2001-005- F00025 from Center of Research Institute
Program in the Korea Research Foundation. |
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1.1.2. KOSEF (Korea Science and Engineering
Foundation) Research Project |
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The institute carried out research project
for the Korea Science and Engineering foundation for the
year 2004. The contents and result of the project are
as follows. This project was carried out for the second
year of the study period and terminated because of resignation
of the PI. The fund of the project was $34,000, for one
year.
Title : The study of the genetic polymorphism associated
with rheumatoid arthritis by Sasang Constitution
Primary investigator : Su-Young Kim, PhD.
East-West Medical Research Institute, Kyung Hee University
Purpose of Research : In order to examine the genetic
polymorphism associated with rheumatoid arthritis by Sasang
Constitution, this study was planned to detect the susceptibility
of the patients diagnosed by rheumatoid arthritis to Sasang
Constitution and to examine the risk factor such as life
style and environmental stress in order to profoundly
study the genetic polymorphism like metabolic gene correlated
with the susceptibility to rheumatoid arthritis by specific
Sasang Constitution. In preliminary, experiment, the genetic
polymorphism of TNF-alpha (G308A), GSTM1, GSTT1 and CYP1A1
were analyzed in rheumatoid arthritis patients and controls.
Contents of Research : This study was planned to detect
the susceptibility of the patients diagnosed by rheumatiode
arthritis to Sasang Constitution and its association with
specific genetic polymorphism.
In order to analyze the susceptibility of rheumatoid arthritis
to Sasang Constitution, 147 rheumatoid arthritis patients
and 147 matched controls were assessed with QSCCⅡ question
for Sasang Constitution. Then the frequencies of patients
by Sasang Constitution were compared to those of the controls,
which were statistically analyzed and adjusted by age,
sex, smoking status and BMI.
On the basis of results obtained during the first year,
specific constitutions which were expected to be related
to rheumatoid arthritis were studied by lifestyle(smoking
and overweight, e.g.) and the hazardous environment for
health, in detail.
Also, the genetic polymorphism of TNF-α(G308), GSTM1,
GSTT1 and CYP1A1 associated with rheumatoid arthritis
according to Sasang Constitution are analyzed with RFLP-PCR
in patients with rheumatoid arthritis and control.
Effectiveness of Research : During the first year, 147
rheumatoid arthritis patients and 147 matched controls
were assessed with QSCCⅡ question for Sasang Constitution.
Soeumin was the most susceptible to rheumatoid arthritis
compared to Taeumin or Soyangin. It was statistically
significant after adjusting age, sex, smoking status,
alchol intake, BMI, and economic status(Adjusted OR[95
3.01[1.47-6.15]). It is suggested that the specific Sasang
Constitution associated with rheumatoid arthritis is used
as basic data to prevent the risk factors for rheumatoid
arthritis. During the second year, differential effect
of passive smoking on the association between Sasang Constitution
and rheumatoid arthritis risk was found. This study showed
that the GSTM1 and CYP1A1 genetic polymorphisms have differential
effects on the association of active and passive smoking
with rheumatoid arthritis and the presence of the heterozyous
or homozyous variant types of CYP1A1 (WM or M/M) appears
to enhance the magnitude of the association between active/passive
smoke exposure and rheumatoid arthritis. The genetic polymorphism
of rheumatoid arthritis patients and controls, such as
TNF-α(G308A), GSTM1, GSTT1 and CYP1A1, associated with
the susceptibility to rheumatoid arthritis by Sasang Constitution
was analyzed for a preliminary results. Differential effects
of TNF-α(G308), GSTM1, GSTT1 and CYP1A1 genetic polymorphism
on the association between rheumatoid arthritis risk and
Sasang Constitution were found. It is suggested that the
genetic polymorphism correlated with susceptibility to
rheumatoid arthritis by specific Sasang Constitution used
as its susceptibility marker and further as basic data
to prevent the risk factors for rheumatoid arthritis.
But larger studies will be needed to confirm these preliminary
findings.
This work is supported by grant No. R03-2002-000-00033-0
from the Basic Research Program of the Korea Science and
Engineering Foundation. |
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1.1.3. Korea Food & Drug Administration
Research Project |
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The institute carried out a six-month research
project for the Korea Food & Drug Administration during
2004. The contents and result of the project are as follows.
The fund of the project was $45,000.
Title : Studies on the Standardization of Processed Herbal
Medicine
Primary Investigator : Nam-Jae Kim, PhD.
East-West Medical Research Institute, Kyung Hee University
Herbal medicines are generally not used in the natural
form, but in the processed form in order to make sure
of their safety, efficacy, stability and uniformity of
quality. Therefore, many herbal medicines are processed
by heating, steaming and mixed frying with honey, wine,
vinegar and brine etc. in order to improve the efficacy,
decrease toxicity and side effects, and change the propertyies
have used in oriental medicine in Korea, China and Japan.
As a study of manufacturing process standardization and
regulation of processed herbal medicines, we have been
analyzing the chemical constituents before and after processing.
Meanwhile, the standardization of processing methods are
necessary for the establishment of the guidelines which
can be used for the application of effective and safe
processed goods. Accordingly, in this study, we planned
that we should select Glycyrrhizae Radix, Evodiae Fructus
and Rhei Rhizoma which are commonly used, and establish
the standard processing methods of processing Glycyrrhizae
Radix by stir-frying and mix-frying with honey, processed
Evodiae Fructus by mix-frying with licoris decoction and
brine respectively, and processing Rhei Rhoma by mix-frying
with vinegar and wine respectively, and char-frying, and
furthermore, bring up the physicochemical parameters for
the standard establishment of processed goods. And also,
we intended that we contribute to the improvement of national
health and welfare by the supply of safe herbal medicines
into clinical medicine, and this could be fulfilled by
security of the control processed goods for quality evaluation
and standard establishment of processed goods.
For the purpose of guidelines for processing of standardized
products of them, physico-chemical examination such as
the contents of loss on drying, water extract, diluter
ethanol, ether, residue on ignition and residue on acid
insoluble ignition were tested. Also, in order to evaluate
the quality control of them quantitative determination
of standard compound from each herbal medicines have conducted
HPLC method was apply to the quantitative analysis of
pre-processed and post-processed.
| (1) |
In frying or frying with watering methods using
heat, manufacturing standardization needs the maintenance
of regular temperature and fixed timely heating
by use of rotary roaster having definite speed for
obtaining the regularly qualified processed goods. |
| (2) |
In progressing method using liquid supplementary
material, for manufacturing of processed Glycyrrhizae
Radix by mix-frying with honey, processed Evodiae
Fructus by mix-frying with licoris decoction and
brine respectively, and processed Rhei Rhoma by
mix-frying with wine, liquid supplementary material
should be used in proper concentration by appropriate
dilution for sufficient absorption. And then, processed
goods should be left for prescribed time in the
airtight space for the purpose of uniform absorption. |
| (3) |
Processed Glycyrrhizae Radix by stir-frying and
mix-frying with honey are progressed goods of Glycyrrhizae
Radix, and their glycyrrhizin(standard component)
becomes glycyrrhetic acid, which is artifact, by
heat decomposition. So, this artifact can be identified
as standard component, and be utilized for the qualification
standard by its quantification. |
| (4) |
As a identification method for processed Evodiae
Fructus by mix-frying with licoris decoction, the
identification of glycyrrhizin through TLC method
can be used by reason of the fact that Glycyrrhizae
Radix should be used for liquid supplementary material. |
| (5) |
As a identification method for processed Evodiae
Fructus by mix-frying with brine, the qualification
method of chloride compound is able to apply, on
account of the reason that salt(NaCl) is used for
supplementary material. |
| (6) |
In the establishment of standard progressing method
of Rhei Rhizoma, diarrhea inducing activity and
large intestine transportation activity are recommended
as the standard of processed Rhei Rhizoma by mix-frying
with vinegar, wine and char-frying, in turn. |
This work is supported by grant No. 04082生藥品521 from the
Research Program of the Korea Food & Drug Administration. |
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1.1.4. Research papers published in 2004 |
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| (1) |
Ji Hoon Kim, Byung-Il Min, Heung Sik Na, Dong
Suk Park
Relieving effects of electroacupuncture on mechanical
allodynia in neuropathic pain model of inferior
caudal trunk injury in rat: mediation by spinal
opioid receptors
Brain Research 998 (2004) 230-236 |
| (2) |
Gi Soon Choi, Jae Bok Han, Joon Ha Park, Sang
Deog Oh, Gi Seog Lee, Hyun Su Bae, Sung Ki Jung,
Young Wuk Cho, Hyun Jong Ahn, Byung Il Min
Effects of Moxibustion to Zusanli (ST36) on Alteration
of Natural Killer Cell Activity in Rats
The American Journal of Chinese Medicine 32(2) 303-312,
2004 |
| (3) |
Eu-Teum Hahm, Jong-Ju Lee, Won-Kyu Lee, Hyun-Soo
Bae, Byung-Il Min, Young-Wuk Cho
Electroacupuncture Enhancement of Natural Killer
Cell Activity Suppressed by Anterior Hypothalamic
Lesions in Rats
Neuroimmunomodulation 2004;11:268-272 |
| (4) |
Hyun-Kyung Chang, Mi-Hyeon Jang, Baek-Vin Lim,
Taeck-Hyun Lee, Min-Chul Shin, Mal-Soon Shin, Hong
Kim, Young-Pyo Kim, Ee-Hwa Kim, Chang-Ju Kim
Administration of Ginseng radix Decreases Nitric
Oxide Synthase Expression in the Hippocampus of
Streptozotocin-Induced Diabetic Rats
The American Journal of Chinese Medicine 32(4) 497-507,
2004 |
| (5) |
Ee-Hwa Kim, Mal-Soon Shin, Hyun-Kyung Chang, Taeck-Hyun
Lee, Mi-Hyeon Jang, Min-Chul Shin, Sam-Jun Lee,
Chang Ju Kim
Aqueous Extract of Ma huang Suppresses Neuropeptide
Y Expression in Food-Deprived Rat Hypothalamus
The American Journal of Chinese Medicine 32(5) 659-667,
2004 |
| (6) |
Byung-Shik Cheong, Do-Young Choi, Nam-Hun Cho,
Jae-Dong Lee, Hyun-Kyung Chang, Min-Chul Shin, Mal-Soon
Shin, Chang-Ju Kim
Modulation of Corydalis tuber on Glycine-Induced
Ion Current in Acutely Dissociated Rat Periaqueductal
Gray Neurons
Biol. Pharm. Bull. 27(8) 1207-1211 (2004) |
| (7) |
Nam-Hun Cho, Jae-Dong Lee, Byung-Shik Cheong,
Do-Young Choi, Hyun-Kyung Chang, Taeck-Hyun Lee,
Min-Chul Shin, Mal-Soon Shin, Jongseok Lee, Chang-Ju
Kim
Acupuncture suppresses intrastriatal hemorrhage-induced
apoptotic neuronal cell death in rats
Neuroscience Letters 362 (2004) 141-145 |
| (8) |
Eun Mi Ju, Si Eun Lee, Hyun Jin Hwang, Jeong Hee
Kim
Antioxidant and anticancer activity of extract from
Betula platyphylla var. japonica
Life Sciences 74 (2004) 1013-1026 |
| (9) |
Jae-Dong Lee, Su-Young Kim, Tae-Woo Kim, Sang-Hoon
Lee, Hyung-In Yang, Doo-Ik Lee, Yun-Ho Lee
Anti-inflammatory Effect of Bee Venom on Type Ⅱ
Collagen-Induced Arthritis
The American Journal of Chinese Medicine 32(3) 361-367
(2004) |
| (10) |
Kim Su-young, Lee Sang-hoon, Lee Hyun-jong, Lee
Doo-ik, Lee Yun-ho, Lee Jae-dong
The case-control study of rheumatoid arthritis by
sasang typology
The Journal of Korean Acupuncture & Moxibustion
Society 21(1)86-98, 2004 |
| (11) |
Lee Hyung-jong, Jung In-tae, Kim Su-young, Lee
Doo-ik, Kim Keon-sik, Lee Jae-dong, Lee Yun-ho,
Choi Do-young
The clinical manifestation of migraine and correlation
study with autonomic bioelectric response
The Journal of Korean Acupuncture & Moxibustion
Society 21(3)215-229, 2004 |
| (12) |
Jung In-tae, Kim Su-young, Kim Keon-sik, Lee Doo-ik,
Lee Jae-dong, Lee Yun-ho, Choi Do-young
A clinical study of Aroma Acupuncture on chronic
headache patients
The Journal of Korean Acupuncture & Moxibustion
Society 21(5) 123-136, 2004 |
| (13) |
Ki-Ho Cho, Young-Suk Kim, Hyung-Sup Bae, Sang-Kwan
Moon, Woo Sang Jung, Eun-Kyung Park, Dong-Hyun Kim
Inhibitory Effect of Chunghyuldan in Prostaglandin
E2 and Nitric Oxide Biosynthesis of Lipopolysaccharide-Induced
RAW 264.7 Cells
Biol. Pharm. Bull. 27(11) 1810-1813 (2004) |
| (14) |
Ki-Ho Cho, Woo-Sang Jung, Sung-Uk Park, Sang-Kwan
Moon, Chang-Nam Ko, Seojin Ku, Sung-Gil Chi, Heonyong
Park
Daio-Orengedokudo works as a cell-proliferating
compound in endothelial cells
Can. J. Physiol. Pharmacol. 82: 380-386 (2004) |
| (15) |
Sunkyung Baek, Youngmin Bu, Hwasu Kim, Hocheol
Kim
Telomerase induction in astrocytes of Sprague-Dawley
rat after ischemic brain injury
Neuroscience Letters 363 (2004) 94-96 |
| (16) |
Choon-Gon Jang, Moonkyu Kang, Jae-Han Cho, Sun-Bok
Lee, Hyuntaek Kim, Soonkwon Park, Jinwoo Lee, Seong-Kyu
Park, Moochang Hong, Min Kyu Shin, In-Sup Shim,
Hyunsu Bae
Nelumbinis Semen Reverses a Decrease in 5-HT1A Receptor
Binding Induced by Chronic Mild Stress, a Depression-like
Symptom
Arch Pham Res 27(10) 1065-1072, 2004 |
| (17) |
Seung-Jae Oh, Sung-Cherl Jung, Oh-Bin Kwon, Young-Sil
Kim, Mei-Ying Kim, Sangeok Kim, Sabina Lim, Hyung-Cheul
Shin
Hypothermia-induced changes of afferent sensory
transmission on the VPM thalamus of rats and hamsters
Brain Research 1003 (2004) 122-129 |
| (18) |
Kyoung-Ah Kim, Ji-Suk Lee, Hi-Joon Park, Jin-Woo
Kim, Chang-Ju Kim, In-Sop Shim, Nam-Jae Kim, Seung-Moo
Han, Sabina Lim
Inhibition of cytochrome P450 activities by oleanolic
acid and ursolic acid in human liver microsomes
Life Sciences 74 (2004) 2769-2779 |
| (19) |
Mi-Jeong Ahn, Kee-Dong Yoon, So-Young Min, Ji
Suk Lee, Jeong Ha Kim, Tae Gyun Kim, Seung Hee Kim,
Nam-Gil Kim, Hoon Huh, Jinwoong Kim
Inhibition of HIV-1 Reverse Transcriptase and Protease
by Phlorotannins from the Brown Alga Ecklonia cava
Biol. Pharm. Bull. 27(4) 544-547 (2004) |
| (20) |
Hun Sung Yoo, Ji Suk Lee, Chul Young Kim, Jinwoong
Kim
Flavonoids of Crotalaria sessiliflora
Arch Pharm Res 27(5), 544-546, 2004 |
| (21) |
Ji Suk Lee, Jinwoong Kim, Young Uck Yu, Young
Choong Kim
Inhibition of Phospholipase C?1 and Cancer Cell
Proliferation by Lignans and Flavans from Machilus
thunbergii
Arch Pharm Res 27(10), 1043-1047, 2004 |
| (22) |
Jin-Kyung Oh, Younbyoung Chae, Insop Shim, Hi-Joon
Park, Hyejung Lee
Acupuncture treatment of drug addiction
Oriental Pharmacy and Experimental Medicine 2004,
4(2), 65-69 |
| (23) |
Sang Yoon Choi, Sanghee Kim, Jae Sung Hwang, Byeong
Gon Lee, Hocheol Kim, Sun Yeou Kim
Benzylamide derivative compound attenuates the ultraviolet
B-induced hyperpigmentation in the brownish guinea
pig skin
Biochemical Pharmacology 67 (2004) 707-715 |
| (24) |
Ho Joong Sung, Yoon Suk Kim, In Sik Kim, Sung-Wuk
Jang, Yoon Rim Kim, Doe Sun Na, Ki Hoon Han, Byung
Gil Hwang, Dong Suk Park, Jesang Ko
Proteomic analysis of differential protein expression
in neuropathic pain and electroacupuncture treatment
models
Proteomics 2004, 4, 2805-2813 |
| (25) |
Moon-Baik Park, Eunjung Ko, Changjoon Ahn, Hyun
Choi, Samwoong Rho, Min-Kyu Shin, Moo-Chang Hong,
Byung-Il Min, Hyunsu Bae
Suppression of IgE production and modulation of
Th1/Th2 cell response by electroacupuncture in DNP-KLH
immunized mice
Journal of Neuroimmunology 151 (2004) 40-44 |
| (26) |
Dongwook Son, Pyeongjae Lee, Jongseok Lee, Hocheol
Kim, Sun Yeou Kim
Neuroprotective effect of wogonin in hippocampal
slice culture exposed to oxygen and glucose deprivation
European Journal of Pharmacology 493 (2004) 99-102 |
| (27) |
Jin Young Hur, Pyeongjae Lee, Hocheol Kim, Insug
Kang, Kang Ro Lee, Sun Yeou Kim
(―)-3,5-Dicaffeoyl-muco-quinic acid isolated from
Aster scaber contributes to the differentiation
of PC12 cells: through tyrosine kinase cascade signaling
Biochemical and Biophysical Research Communications
313 (2004) 948-953 |
| (28) |
Eun-Ok Lee, Byoung-Mog Kwon, Gyu-Yong Song, Chan-Hee
Chae, Hyung-Min Kim, In-Sop Shim, Kyoo-Seok Ahn,
Sung-Hoon Kim
Heyneanol A induces apoptosis via cytochrome c release
and caspase activation in human leukemic U937 cells
Life Sciences 74 (2004) 2313-2326 |
| (29) |
Jeong-Eun Huh, Kyung-Sun Kang, Chanhee Chae, Hyung-Min
Kim, Kyoo-Seok Ahn, Sung-Hoon Kim
Roles of p38 and JNK mitogen-activated protein kinase
pathways during cantharidin-induced apoptosis in
U937 cells
Biochemical Pharmacolgoy 67 (2004) 1811-1818 |
| (30) |
Eun-Suk Ha, Eun-Ok Lee, Taek-Joon Yoon, Jin-Hyung
Kim, Jong-Oh Park, Nak-Cheol Lim, Sung-Ki Jung,
Byung-Soo Yoon, Sung-Hoon Kim
Methylene Chloride Franction of Spatholobi Caulis
Induces Apoptosis via Caspase Dependent Pathway
in U937 Cells
Biol. Pharm. Bull. 27(9) 1348-1352 (2004) |
| (31) |
Sung Hoon Kim, Seung-Ae Kim, Mi-Kyung Park, Seung-Hyung
Kim, Young-Doo Park, Ho-Jeong Na, Hyung-Min Kim,
Min-Kyu Shin, Kyoo-seok Ahn
Paeonol inhibits anaphylactic reaction by regulating
histamine and TNF-α
International Immunopharmacology 4 (2004) 279-287 |
| (32) |
Min-Jong Kim, Ha-Na Kim, Kyung-Sun Kang, Nam-In
Baek, Dae-Keun Kim, Young-Seol Kim, Sung-Hoom Kim,
Byung-Hun Jean
Methanol extract of Dioscoreae Rhizoma inhibits
pro-inflammatory cytokines and mediators in the
synoviocytes of rheumatoid arthritis
International Immunopharmacology 4 (2004)1489-1497 |
| (33) |
Dong Hak Youhn, Hi-Joon Park, Seung-Tae Kim, Soo-Hee
Jin, Su-Jin Lee, Hye-Jung Lee, Sabina Lim
The association of genetic polymorphism between
responder and nonresponder to acupuncture in smoking
cessation
The Korean Journal of Meridian & Acupoint 21(1),
41-50, 2004 |
| (34) |
Sabina Lim, Hyung-Taeck Lim, Hi-Joon Park, Ji-Ryeon
Jang Il-Hwan Choi, Seok-Chan Lee, Dae-Soo Kim, Hee-Sup
Shin
The analgesic mechanism of Acupuncturing at ST36
in the abdominal pain of the mouse
The Korean Journal of Meridian & Acupoint 21(2),
69-79, 2004 |
| (35) |
Hi-Joon Park, Youn-Byoung Chae, Wung-Seok Cha,
Jong-Bae Park, Hye-Jung Lee, Hyang-Sook Lee, Chang-Sik
Yin, Hyung-Kyun Koh, Su-Young Kim, Il-Hwan Choe,
Kang-Sik Kim, Jung-Bae Moon, Ki-Tae Bae, Kyoung-Hwan
Rheu, Keun-Yung Yook, Byeong-Ju Jeong, In-Chul Sohn,
Sabina Lim
Comparative study between proportional method and
directional method in locating acupoints at forearm
The Korean Journal of Meridian & Acupoint 21(4),
31-41, 2004 |
| (36) |
Bo-Rim Seo, Kyung-Won Lee, Joohun Ha, Hee-Jun
Park, Jong-Won Choi, Kyung-Tae Lee
Saucernetin-7 isolated from Saururus chinensis inhibits
proliferation of human promyelocytic HL-60 leukemia
cells via G0/G1 phase arrest and induction of differentiation
Carcinogenesis 25(8), 1387-1394, 2004 |
| (37) |
Kyung-Min Shin, Rung-Kyu Kim, Tapondjou Leon Azefack,
Lontsi David, Sondengam Beibam Luc, Muhammad Iqbal
Choudhary, Hee-Juhn Park, Jong-Won Choi, Kyung-Tae
Lee
In vitro Anti-Inflammatory Activity of 23-Hydroxyursolic
Acid Isolated from Cussonia bancoensis in Murine
Macrophage RAW 264.7 Cells
Planta Med 2004; 70: 803-807 |
| (38) |
Kyung-MIn Shin, In-Tae Kim, Young-Mi Park, Joohun
Ha, Jong-Won Choi, Hee-Juhn Park, Yong Sup Lee,
Kyung-Tae Lee
Anti-inflammatory effect of caffeic acid methyl
ester and its mode of action through the inhibition
of prostaglandin E2, nitric oxide and tumor necrosis
factor-α production
Biochemical Pharmacology 68 (2004) 2327-2336 |
| (39) |
Seoung-Hee Jeong, Sung-Ja Koo, Joo-Hun Ha, Shi-Yong
Ryu, Hee-Juhn Park, Kyung-Tae Lee
Induction of Apoptosis by Yomogin in Human Promyelocytic
Leukemic HL-60 Cells
Biol. Pharm. Bull. 27(7) 1106-1111 (2004) |
| (40) |
Young-Mi Park, In-Tae Kim, Hee-Juhn Park, Jong-Won
Choi, Kun-Young Park, Jae-Dong Lee, Byung-Hyouk
Nam, Deog-Gon Kim, Jin-Yong Lee, Kyung-Tae Lee
Anti-inflammatory and Anti-nociceptive Effects of
the Methanol Extract of Fomes fomentarius
Biol. Pharm. Bull. 27(10) 1588-1593 (2004) |
| (41) |
Seo Byung-kwan, Ryu Seong-ryong, Lee Song-shil,
Huh Jeong-eun, Baek Yong-hyeon, Lee Jae-dong, Choi
Do-young, Cho Yoon-je, Kim Nam-jae, Park Dong-suk
Systemic review: Herbal Medicines in the Treatment
of Osteoarthritis in Pubmed and Chinese Medical
Journals
The Journal of Korean Acupuncture & Moxibustion
Society 21(3) 265-282 |
| (42) |
Nam-Jae Kim
Concurrent Use of Herbal Medicines and Pharmaceutical
Drugs and Its Problems
The Korean Journal of Joongpoong 2004;5(1):15-33 |
| (43) |
Hyoun-Jung Choi, Na-Young Bhang, Bo-Wan Song,
Nam-Jae Kim, Bong-Ha Ryu
Survey on the Preference for the Dosage Forms of
Oriental Herbal Medicine
The Journal of Kyung Hee University Medical Center
20(1),46-57,2004 |
The full contents of Nos. 1-9, 13-32, and 36-40 were written
in English. |
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.1.5. Publications in 2004 |
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| (1) |
East-West Medical Research Institute Journal 2003
:
This book contains 47 articles which were researched
and published in this institute. |
| (2) |
Papers of the 2004 International Conference on
Oriental Medicine :
This book contains 24 articles which were presented
the international conference organized by this institute.
Titles of th Presented papers ar listed in section
1.2.1. |
| (3) |
Quality Control of Herbal Medicines
This book is written by Nam-Doo Hong(former director)
and Nam-Jae Kim(Chief, Division of Pharmacological
Study) in Korean. |
| (4) |
Studies of Oriental Hospital Pharmacy
This book is also written by Nam-Doo Hong(former
director) and Nam-Jae Kim(Chief, Division of Pharmacological
Study) in Korean. |
These publications are attached separately on this document. |
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1.2. Further Activity |
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1.2.1. 2004 International Conference on
Oriental Medicine |
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Outline of the International Conference
:
| Title |
2004
International Conference on Oriental Medicine |
| Main Theme |
Evidence-Based
Approach to Oriental Medicine 2004 |
| Date |
August
27 (Friday), 2004, 08:30 ~ 17:00 |
| Venue |
COEX
Grand Ballroom #102, Seoul, Korea |
| Host |
Institute
of Oriental Medicine, College of Oriental
Medicine and
East-West Medical Research Institute, Kyung
Hee University |
Supporting
Organization |
World
Health Organization
Ministry of Health and Welfare, Republic of
Korea
Korea Research Foundation
JoongAng Ilbo
The Association of Korean Oriental Medicine
Korean Oriental Medical Society |
Participating
Nations |
USA,
Hong Kong, Japan, China, Korea |
| Program |
Welcoming
Party : August 26 (Thursday) 18:30 - 20:30
Sorak
Room, The Ritz-Carlton, Seoul, Korea
Conference : August 27 (Friday) 08:30 - 17:00
COEX
Grand Ballroom #102, Gangnam-ku,
Samsung-dong, Seoul, Korea |
| Invited Speakers |
Abroad
: 6 (USA 2, Japan 1, China 2, HongKong 1)
Domestic : 12 |
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Scientific Programme :
| August
27 (Friday) |
| 08:30-09:20 |
RegistrationCOEX
Grand Ballroom #102 |
|
| OPENING
CEREMONY |
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Chairman
: Prof. Houng-Yeoul Kim
Dept.
of Preventive Medicine, College of Oriental
Medicine,
Kyung
Hee University, Korea |
| 09:20-09:25 |
Opening
address
- Hyung-Koo Rhee
Director,
institute of Oriental Medicine, Kyung
Hee University
President
of Organizing Committee |
| 09:25-09:35 |
Welcoming
address (1)
- Choong Yoon
Vice-President
for Medical Affairs, Kyung Hee University
Director
General, Kyung Hee University Medical
Center
Welcoming address (2)
- Jae-Kyu An
President,
The Association of Korean Oriental Medicine |
| 09:35-09:50 |
Congratulatory
address (1)
- Jai-Seong Song
Vice-Minister,
Ministry of Health and Welfare, Republic
of Korea
Congratulatory address (2)
- Seung-Hoon Choi
Regional
Adviser, WHO Regional Office for the
Western Pacific |
|
| SPECIAL
SESSION |
| |
Chairman
: Prof. Houng-Yeoul Kim
Dept.
of Preventive Medicine, College of Oriental
Medicine,
Kyung
Hee University, Korea |
| 09:50-10:10 |
WHO
Traditional Medicine Strategy
- Seung-Hoon Choi (Regional Adviser,
WHO Regional Office for the Western
Pacific) |
| 10:10-10:30 |
Inhibition
of inflammation prevents neurodegeneration:
foresight of Oriental medicine
- Jae-Kyu An
Tong
H. Joh (Weill Medical College of Cornell
University, USA) |
|
| SESSION
Ⅰ |
| |
Chairman
: Prof. Moo-Chang Hong
Dept.
of Physiology, College of Oriental Medicine,
KHU., Korea
Prof.
Hyun-Su Bae
Dept.
of Physiology, College of Oriental Medicine,
KHU., Korea |
| 10:30-11:00 |
The
changes of tongue manifestation in the
course of Chronic Obstructive Pulmonary
Disease(COPD) and its clinical significance
- TaoKai (Affiliated Hospital of Shandong
College of TCM, China) |
| 11:00-11:15 |
A
clinical preliminary study on the preventive
effects of Chunghyul-dan on ischemic
stroke recurrence.
- Woo-Sang Jung (College of Oriental
Medicine, Kyung Hee University, Korea) |
| 11:15-11:30 |
Randomized
controlled double-blind study of bee
venom therapy on rheumatoid arthritis
- Jae-Dong Lee (College of Oriental
Medicine, Kyung Hee University, Korea) |
| 11:30-11:45 |
The
investigation of the clinical trial
cases by molecular biochemical methods
- Hong-Yeoul Kim (College of Oriental
Medicine, Kyung Hee University, Korea) |
| 11:45-12:00 |
Correlation
between healthy Korean women's skin
condition and Sasang Constitution
- Soo-Kyung Lee (College of Oriental
Medicine, Kyung Hee University, Korea) |
| 12:00-13:00 |
Luncheon |
|
| SESSION
Ⅱ |
| |
Chairman
: Prof. Moo-Chang Hong
Dept.
of Physiology, College of Oriental Medicine,
KHU., Korea
Prof.
Hyun-Su Bae
Dept.
of Physiology, College of Oriental Medicine,
KHU., Korea |
| 13:00-13:30 |
Danggui
Buxue Tang (A Chinese Angelica Decoction):
A sample trial in Traditional Chinese
Medicine standardization
- Karl W. K. Tsim (Hong Kong Univ. of
Science and Technology, Hong Kong) |
| 13:30-14:00 |
Reliability
of IR thermography readings on twelve
acupuncture point
- Clark D. Danielson (South Baylo University,
USA) |
| 14:00-14:15 |
Effectiveness
of East-West pain treatment for central
poststroke pain on alleviation of pain
and rehabilitation
- Doo-Ik Lee (College of Medicine, Kyung
Hee University, Korea) |
| 14:15-14:30 |
In
vivo investigation of the protective
effects of herbal acupuncture of safflower
oil cake on cytokines-induced apoptosis
of hair bulb keratinocytes
- Tae-Hoo Yi (Research Group of Pain
and Neuroscience in Vision 2000 Project,
East-West Medical Research Institute,
Kyung Hee University, Korea) |
| 14:30-14:45 |
Reduction
of microglial activation of substantia
nigra in rat model of Parkinson's disease
by acupuncture stimulation
- Hi-Joon Park (College of Oriental
Medicine, Kyung Hee University, Korea) |
| 14:45-15:00 |
The
case-control study of rheumatoid arthritis
by Sasang typology
- Su-Young Kim (East-West Medical Research
Institute, Kyung Hee Univ., Korea) |
| 15:00-15:10 |
Coffee
Break |
|
| SESSION
Ⅲ |
| |
Chairman
: Prof. Sabina Lim
Dept.
of Meridian & Acupoint, College
of Oriental Medicine,
Kyung
Hee University, Korea
Prof.
Young-Chul Kim
Dept.
of Liver System, College of Oriental
Medicine,
Kyung
Hee University, Korea |
| 15:10-15:40 |
About
an improvement effect of glucose tolerance
in a Ⅱ type diabetes mellitus model
animal of Fuscoporia oblique
- Ikukatsu Suzuki (Suzuka University
of Medical Science, Japan) |
| 15:40-16:10 |
The
model of Song-Dynasty's Tiansheng bronze
statue showing acupoints
- A Specification for the First National
Standard of Acupoints in the World
- Huang Longxiang (WHO Collaborating
Centre, China Academy of TCM, China)
|
| 16:10-16:25 |
The
study of clinical herbal therapy on
disk patients of Jaseng Oriental Medical
Hospital
- Joon-Shik Shin (Jaseng Oriental Medical
Hospital, Korea) |
| 16:25-16:40 |
Clinical
Report of the changes in growth hormone
and height-growth ratio after administration
of Korean medical prescription
- Seung Man-Park (Jese Korean Medical
Clinic, Korea) |
| 16:40-16:55 |
Proteome
analysis of red deer antler
- Byoung-Chul Park (Intelligence Bioinformatics
and Application Center, KRIBB, Korea) |
|
| CLOSING
CEREMONY |
| 16:55-17:00 |
Closing
address
- Hyung-Koo Rhee
Director,
Institute of Oriental Medicine, Kyung
Hee University
President
of Organizing Committee |
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1.2.2. Foreign Visiter |
| |
| (1) |
Hong Kong, Tung Wah Group of Hospitals, 7 June
2004
ㆍ Mr. Eddle Wang, Chairman, Medical and Health Committed,
TWGHs
ㆍ Mr. Leung Kam-fong, Chief Executive, TWGHs
ㆍ Dr, C C Luk, Hospital Chief Executive, Kwong Wah
Hospital and TWGHs Wong Tai Sin Hospital
ㆍ Dr. K T Tom, Hospital Chief Executive, Tung Wah
Hospital and Tung Wah Eastern Hospital
ㆍ Dr. Cissy YU, Hospital Chief Executive, TWGHs
Fung Yiu King Hospital
ㆍ Dr. Andrew YIP, Chief of Service (Surgery), Kwong
Wah Hospital
ㆍ Dr. Chan Ming-Houng, Consultant(Geriatrics), Kwon
Wah Hospital
ㆍ Dr. Wong Wing-cheung, Consultant(Orthopaedics
& Traumatology), Kwong Wah Hospital
ㆍ Dr. Hui Pak-kwan, Consultant(Pathology), Kwong
Wah Hospital
ㆍ Dr. Felix Chan, Consultant(Geriatrics), TWGHs
Fung Yiu King Hospital
ㆍ Mr. Philip Tam Wai-chiu, Consultant(Medical Services),
TWGHs
ㆍ Ms. Rira Li, Medical Services Secretary, TWGHs
ㆍ Ms. Priscilla Lui, Executive Officer(Medical),
TWGHs
ㆍ Ms. ZHU Dan, Chinese Medicine Practitioner, TWGHs-HKU
Clinical Centre for Teaching and Research in Chinese
Medicine
ㆍ Ms. Jasmine Tam, Executive Officer(Medical) |
| (2) |
Twain, Taiwan PhytoMedicine Mission to Korea,
13 September 2004
ㆍ Lain-Tze Lee, Director Pharmaceutical Technology
Division, Biomedical Engineering Center, Industrial
Technology Research Institute
ㆍ Chung-Gung Shen, Chairman, Sun Ten Pharmaceutical
Co.k Ltd.
ㆍ Tsu-Tai Lin, Ph.D., Researcher, International
Development Manager, Program Office fo Herbal medicines,
DoIT, MoEA
ㆍ Sylvia Lin, Associate Researcher, Program Office
of Herbal Medicines, DoIT, MoEA
ㆍ Re Yi Wu Ph.D., Chinese Herbal Med. Project, Development
Center for Biotechnology
ㆍ Ko Ph.D., Researcher, Natural Pharmaceutical Division,
Pharmaceutical Industry Technology and Development
Center
ㆍ 吳孝芸 Ph.D., Pharmaceutical Industry Technology
and Development Center
ㆍ Chou, Liang Ying, Pharmacist, R&D Manager,
Sheng Vhang Pharmaceutical Co., Ltd.
ㆍ Mr. Hung, Kaiser Pharmaceutical Co., Ltd.
ㆍ Richard J.K. Yang, Ph.D., B. Representative, Scientific
Pharmaceutical Elite Company
ㆍ Jir-Mehng Lo, Ph.D., Researcher, Pharmaceutical
Technology Division, Biomedical Engineering Center,
Industrial Technology Research Institute |
|
| |
|
| |
1.2.3. International Congress Attendance |
| |
| (1) |
The 55th Annual Congress of Society of Kampo Medicine
25 June - 27 June, 2004, JAPAN
Professor Young-Seol Kim(former director) and Professor
Ki-Ho Cho(vice director) attended the meeting. Professor
Cho presented two lectures - 'For the globalization
of Herbal Medicine' and 'Effect of Hyolboochuko-tang
on the Prognosis of Patiets with Middle Cerebral
Artery Stenosis'. |
| (2) |
The 4th Annual Congress of Japanese Association
for Alternative, Complementary and Traditional Medicine
31 July - 1 August, 2004, JAPAN
Professor Young-Seol Kim(former director) attended
the meeting. |
|
| |
|
| |
1.2.4. Newly acquired research equipments
in 2004 |
| |
| (1) |
High Performance Liquid Chromatography |
| (2) |
Ultra Low Temperature Freezer (-80℃) |
| (3) |
Low Temperature Freezer (-30℃) |
| (4) |
Refrigerator (-20℃) |
|
| |
|
| 2. Collaboration between the centre and
the WHO |
| |
|
| |
2.1. Visits by WHO staff (HQ and /or Regional
Office) to the centre |
| |
Name of WHO staff : Dr. Seung-Hoon Choi
Regional Adviser, WHO Regional Office for the Western
Pacific
Dr. Seung-Hoon Choi visited the institute on 7 June 2004
and gave a lecture on 'WHO traditional medicine strategy'. |
| |
|
| |
2.2. Visits by centre staff to the WHO
(HQ and /or Regional Office) |
| |
- None. |
| |
|
| |
2.3. Use of the centre staff by WHO |
| |
We were requested to support and collaborate
on a project on traditional medicine from the World Health
Organization (WHO). These requests from WHO numbered four
items during the year of 2004. All of them were answered.
| (1) |
WHO monographs on selected medicinal plants, Volume
4 (Dr. Xiaorui Zhang, Coordinator, Traditional Medicine,
Department of Essential Drugs and Medicines Policy
(from 2 February, 2004 to the end of May, 2004). |
| (2) |
WHO guidelines on basic training and safety of
chiropractic (Dr. Xiaorui Zhang, Coordinator, Traditional
Medicine, Department of Essential Drugs and Medicines
Policy (from 12 May, 2004 to the end of July, 2004). |
| (3) |
WHO monographs on selected medicinal plants, Volume
4 (Dr. Xiaorui Zhang, Coordinator, Traditional Medicine,
Department of Essential Drugs and Medicines Policy
(from 15 April, 2003 to the end of 15 July, 2004). |
| (4) |
Homeopathy: review and analysis of reports on
controlled clinical trials (Dr. Xiaorui Zhang, Coordinator,
Traditional Medicine, Department of Essential Drugs
and Medicines Policy (from 8 December, 2004 to the
end of January, 2005). |
|
| |
2.4. Support provided by centre staff for
courses cosponsored or organized by the WHO (HQ and /or
Regional Office) |
| |
- None |
| |
|
| |
2.5. WHO financial support to the centre
through contractual or Technical Services Agreement |
| |
- None |
| |
|
| |
2.6. Other type of support provided by the
WHO |
| |
- None |
| |
|
| |
2.7. Any other collaborative activities |
| |
- None |
| |
|
| |
2.8. Any difficulties encountered in the
collaboration |
| |
- None |
| |
|
| |
2.9. Suggestions for increased and improved
collaboration with the WHO |
| |
- None |
| |
|
| 3. Collaboration with other WHO collaborating
centres |
| |
|
| |
WHO Informal Consultation on Development
of 'Treatment Guidelines on Evidence- based Traditional
Medicine'. Natural Products Research Institute, Seoul
National University, 27 May - 29 May, 2004, Seoul, Republic
of KOREA
Professor Sabina Lim(chief, Division of Acupuncture &
Meridian) attended the meeting as an observer. |
| |
|
| 4. Research works to be planned in 2005 |
| |
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| |
4.1. KRF (Korea Research Foundation) Research
Project |
| |
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| |
Contents of Research : |
| |
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| |
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| |
Expected result : |
| |
Establishing
the place of Korean Oriental medicine in the
world by
contributing to human health and welfare |
|
Institute (research environment)
ㆍ establishing a world-class research
basis
ㆍ improving the quality of research
|
|
|
| |
Nationally
ㆍ ensure international competence
of
technology
based on traditional knowledge
ㆍ contribute to human health and
welfare
|
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|
|
Establishing
the place of Korean Oriental medicine
in the world
ㆍ increase international research
productivity
ㆍ facilitate overseas expansion
of Korean
Oriental
medicine technology |
|
|
| |
Student
ㆍ attain knowledge as an international
person
ㆍ cultivating ability to advance
into the
international
society |
|
|
| |
Education
ㆍ train international professionals;
educate
Korean
Oriental medicine to foreigners
ㆍ insure competitiveness in the
course of
education |
|
|
|
| Study
of clinical treatments in East-West medical
sciences |
|
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| |
|
| |
4.2. Personal research works to be planned |
| |
| (1) |
Byung-Il Min
ㆍ Effects of electroacupuncture on cold allodynia
in a rat model of neuropathic
pain : mediation by spinal adrenergic and serotonergic
receptors |
| (2) |
Young-Wuk Cho
ㆍ Modulatory mechanisms of opioid on synaptic transmission
in neuropathic animal model
ㆍ Modulation of neuronal excitability by hypoxia,
ischemia and reactive oxygen species |
| (3) |
Doo-Ik Lee
ㆍ Study of Gene Polymorphism in Central Poststroke
Pain |
| (4) |
Chang-Ju Kim
ㆍ Development of a natural new analgesic containing
amygdalin
ㆍ Development of new ergogenic aid by suppressing
fatigue from medicinal herbs
ㆍ Effect of maternal treatment of medicinal herbs
on neurogenesis and cognition in rat pups |
| (5) |
Jung-Hee Kim
ㆍ Antioxidative activity and anticancer activity
of natural products |
| (6) |
Sung-Hoon Kim
ㆍ Study on the isolation of effective compounds
and development of new functional materials from
chinese cabbage
ㆍ Development of new active materials from domestic
plant sources
ㆍ Study on mechanism of anti-metastasis and apoptosis-inducing
activity of KMKKT and its constituent herbs
ㆍ Production for Korea oldenlandia diffusa as a
functional food |
| (7) |
Sabina Lim
ㆍ Development of Applied Oriental Therapeutic Technology
ㆍ Development of acupuncture therapeutic methods
on Parkinson's disease
ㆍ Experiment on the prevention of depilation and
hair growth effects using the chief ingredients
of the safflower seed
ㆍ Study on the weight loss effects through the use
of rhythm care products |
| (8) |
Dong-Suk Park
ㆍ Korean Medicinal New Drug Development
ㆍ Development of Ceramic Acupuncture |
| (9) |
Jae-Dong Lee
ㆍ A Clinical Study of Bee venom on Allergic inflammation
|
| (10) |
Ho-Cheol Kim
ㆍ Study on the neuroprotective effect of medicinal
herbs in traditional Korean medicine in brain ischemia
rat model
ㆍ Isolation of single compounds which has neuroprotective
effects
?Study on the neuroprotective mechanism of antiinflammation |
| (11) |
Ji-Suk Lee
ㆍ Developments of anti-angiogenic agents for anti-inflammatory
and anti-cancer agents from natural sources
ㆍ Developments of therapeutic agents for cancer
from herbal medicine
ㆍ Developments of therapeutic agents for rheumatoid
arthritis from herbal medicine |
| (12) |
Nam-Hyun Cha
ㆍ A Study on Type A Behavior Pattern(TABP), Stress,
Depression and HIT-6 in the Patients with Chronic
Headache
ㆍ Effects of Acupuncture Therapy and Stellate-ganglion
Block Therapy on Type A Behavior Pattern(TABP),
Stress, Depression and HIT-6 applied to Chronic
Headache Patients
ㆍ Effects of Je tong dan on VAS and Satisfaction
applied to Knee Osteoarthritis Patients
ㆍ Effects of Je tong dan on WOMAC, Lequesne's Functional
Index, and KHAQ in the Patients with Knee osteoarthritis
ㆍ A Study on WOMAC, Lequesne's Functional Index,
and KHAQ of Knee Osteoarthritis Patients |
| (13) |
Hyun-Su Bae
ㆍ Development of herbal medicine effective on Allergic
Diseases
ㆍ Cloning, Purification and functional analysis
of immune modulative effectors from Deer velvet
cDNA library |
| (14) |
Hee-Jae Jung
ㆍ Management of hyperhidrosis |
| (15) |
Nam-Jae Kim
ㆍ Studies on the Standardization of Herbal Medicines
ㆍ Studies on the Efficacy of Combined Preparation
of Crude Dug
ㆍ Studies on the Crude Drug Processing
ㆍ Studies on the Development of Anti-oxidative Drugs
from the Oriental Medicines
ㆍ Study on the Chemical Constituents and Biological
Activities of Bioconversioned Ginseng |
| (16) |
Kyung-Tae Lee
ㆍ Evaluation and studies on the mechanism of apoptosis
by natural compounds
ㆍ Eveluation of in vitro and in vivo anti-inflammatory
activities of various natural compounds
ㆍ Screening and mechanism of cell-cycle inhibitors
isolated from natural compounds
ㆍ In vivo and In vitro nephroprotective effect of
isoprenoid compounds |
|
| |
|
| |
4.3. WHO working group meeting |
| |
Our institute is planning to hold a WHO
working group meeting together with WPRO in August 2005. |
| |
Outline of the meeting :
| Title |
WHO Working Group Meeting on the Revision
of Guidelines for Clinical Research on Acupuncture |
| Date |
August 24 (WED) - 26 (FRI), 2005 |
| Venue |
COEX, World Trade Center Samsung-dong,
Seoul, KOREA |
| Host |
WHO Regional Office for the Western Pacific
East-West Medical Research Institute, Kyung
Hee University, Seoul, KOREA |
Participating
Nations |
KOREA, CHINA, JAPAN, USA, UK, GERMANY, VIETNAM
etc. |
| Number of Invited Experts |
15 - 20 Scholars (except Observers) |
|
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- END - |
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